Table 1 Mediation effects and proportions of each gut microbiota
Immune cell | Gut microbiota | Outcome | Mediated effect | Mediated proportion | Direct effect | P-value |
|---|---|---|---|---|---|---|
FSC-A on NK | Unclassified CAG-977 | CRC | 0.0142 (0.00152, 0.027) | 11% (1.17%, 20.8%) | 0.116 | 0.028 |
NKT %lymphocyte | Unclassified CAG-977 | CRC | 0.0116 (0.00186, 0.0213) | 12.3% (1.99%, 22.6%) | 0.082 | 0.019 |
CD33 on Im MDSC | Order Francisellales | CRC | 0.00959 (0.00258, 0.0166) | -29.9% (-8.05%, -51.8%) | -0.042 | 0.007 |
EM CD8br %CD8br | Order Francisellales | CRC | -0.014 (-0.028, -0.000114) | 22.3% (44.4%, 0.182%) | -0.049 | 0.048 |
BAFF-R on sw mem | Genus Megamonas | CRC | 0.00296 (0.000369, 0.00555) | -9.37% (-1.17%, -17.6%) | -0.035 | 0.025 |
CD39 + CD8br AC | Family Succinivibrionaceae | CRC | 0.00746 (0.000748, 0.0142) | -10.4% (-1.05%, -19.8%) | -0.079 | 0.029 |
CD39 + CD8br %T cell | Family Succinivibrionaceae | CRC | 0.00766 (0.00073, 0.0146) | -9.6% (-0.915%, -18.3%) | -0.087 | 0.030 |
CD39 + CD8br %CD8br | Family Succinivibrionaceae | CRC | 0.00777 (0.000764, 0.0148) | -11% (-1.08%, -20.9%) | -0.079 | 0.030 |