Table 1 Approved HPV vaccines
From: Prophylactic vaccines against HPV-caused cervical cancer: novel vaccines are still demanded
| Â | Vaccine name | Company | Type and amount of L1 VLP | Year approved/ approving authority | Adjuvant | Expression system | Vaccination schedule [28]* | Reference |
|---|---|---|---|---|---|---|---|---|
1 | Cervarix® | GlaxoSmithKline (GSK) | 20 µg HPV-16, 20 µg HPV-18 | 2009/ US-FDA | AS 04: 500 µg aluminum hydroxide and 50 µg 3-O-desacyl-4’ monophosphoryl lipid A (MPL) | Baculovirus (insect) cells | 9–14 years: 2 doses with a minimum of 5-month interval 15 years and above: 3 doses administered at 0, 1–2, 6 months | [29] |
2 | Gardasil® | Merck Sharp & Dohme (MSD) | 20 µg HPV-6, 40 µg HPV-11, 40 µg HPV-16, 20 µg HPV-18 | 2006/ US-FDA | 225 µg amorphous aluminum hydroxy phosphate sulfate | Saccharomyces cerevisiae | 9–13 years: 2 doses with a minimum of 5-month interval 14 years and above: 3 doses administered at 0, 1–2, 6 months | [30] |
3 | Gardasil®9 | Merck Sharp & Dohme (MSD) | 30 µg HPV-6, 40 µg HPV-11, 60 µg HPV-16, 40 µg HPV-18, 20 µg HPV-31, 20 µg HPV-33, 20 µg HPV-45, 20 µg HPV-52, 20 µg HPV-58 | 2014/ US-FDA | 500 µg amorphous aluminum hydroxy phosphate sulfate | S. cerevisiae | 9–14 years: 2 doses with a minimum of 5-month interval 15 years and above: 3 doses administered at 0, 1–2, 4–6 months | [31] |
4 | Cecolin® | Xiamen Innovax Biotech | 40 µg HPV-16, 20 µg HPV-18 | 2019/ China-FDA | 208 µg aluminum hydroxide | Escherichia coli | 9–14 years: 2-dose schedule at months 0, 6 15 years and above 3-dose schedule at 0, 1–2, 5–8 months | [32] [33] |
5 | Walrinvax® | Walvax Yuxi Zerun Biotechnology Co | 40 µg HPV-16, 20 µg HPV-18 | 2022/ China-FDA | 225 µg aluminum phosphate | Pichia pastoris | 9–14 years: 2-dose schedule at 0, 6 months From age 15: 3-dose schedule at 0, 2–3, 6–7 months | [34] |
6 | Cervavac® | Serum Institute of India | 20 µg HPV-6, 40 µg HPV-11, 40 µg HPV-16, 20 µg HPV-18 | 2022/ Indian FDA | 1.25 µg Al3+ | Hansenula polymorpha | 9–26 years (girls and boys) 9–14 years: 2 doses at months 0, 6 15–26 years: 3-dose schedule at 0, 2, 6 months | [35] |