Table 1 Characteristics of triage strategies
Triage strategies | Positive | CIN2_M | CIN3_M | CC_M | Incremental cost, USD | Incremental QALYs | INBs, USD |
|---|---|---|---|---|---|---|---|
HPV16/18+ | |||||||
All | 1538 | 160 | 101 | 4 | 162,095.35 | − 101.38 | − 1,440,902.67 |
< 35 | 131 | 17 | 16 | 0 | 25,999.44 | − 19.65 | − 273,864.54 |
35–50 | 821 | 96 | 61 | 1 | 102,612.11 | − 63.13 | − 898,933.93 |
50+ | 586 | 47 | 24 | 3 | 33,483.80 | − 18.60 | − 268,104.20 |
HPV16/18/31/33/35/45/52/58+ | |||||||
All | 3269 | 56 | 23 | 1 | 36,495.23 | − 8.26 | − 140,686.87 |
< 35 | 275 | 8 | 6 | 0 | 10,156.14 | − 6.90 | − 97,192.74 |
35–50 | 1796 | 31 | 11 | 0 | 18,426.43 | − 0.18 | − 20,696.95 |
50+ | 1198 | 17 | 6 | 1 | 7912.66 | − 1.18 | − 22,797.18 |
p16+ | |||||||
All | 1727 | 58 | 23 | 0 | 108,786.55 | 37.59 | 365,373.71 |
< 35 | 145 | 9 | 9 | 0 | 20,768.69 | − 7.56 | − 116,130.53 |
35–50 | 934 | 33 | 12 | 0 | 59,601.60 | 23.61 | 238,214.94 |
50+ | 648 | 16 | 2 | 0 | 28,416.26 | 21.54 | 243,289.30 |
ASC-US+ | |||||||
All | 1242 | 131 | 55 | 2 | 179,940.97 | − 17.57 | − 401,568.95 |
< 35 | 131 | 16 | 8 | 0 | 23,383.84 | − 8.04 | − 124,800.40 |
35–50 | 702 | 75 | 32 | 0 | 106,399.40 | − 11.49 | − 251,334.26 |
50+ | 409 | 40 | 15 | 2 | 50,157.73 | 1.96 | − 25,434.29 |
HPV16/18+ or (OH-HPV+ and p16+) | |||||||
All | 2467 | 38 | 6 | 0 | 87,265.66 | 45.96 | 492,473.78 |
< 35 | 218 | 3 | 2 | 0 | 9395.88 | 2.10 | 17,093.52 |
35–50 | 1327 | 25 | 3 | 0 | 49,758.37 | 27.15 | 292,711.73 |
50+ | 922 | 10 | 1 | 0 | 28,111.41 | 16.71 | 182,668.53 |
HPV16/18+ or (OH-HPV+ and ASC-US+) | |||||||
All | 2278 | 73 | 6 | 0 | 104,826.00 | 40.08 | 400,743.12 |
< 35 | 218 | 7 | 0 | 0 | 9178.90 | 3.60 | 36,231.50 |
35–50 | 1251 | 41 | 5 | 0 | 60,539.11 | 21.33 | 208,517.51 |
50+ | 809 | 25 | 1 | 0 | 35,107.99 | 15.15 | 155,994.11 |
HPV16/18+ or (HPV31/33/35/45/52/58+ and p16+) | |||||||
All | 2122 | 77 | 27 | 1 | 129,077.97 | 13.58 | 42,220.15 |
< 35 | 176 | 9 | 6 | 0 | 17,409.72 | − 4.26 | − 71,145.36 |
35–50 | 1128 | 46 | 14 | 0 | 73,075.02 | 10.68 | 61,642.50 |
50+ | 818 | 22 | 7 | 1 | 38,593.23 | 7.16 | 51,723.01 |
HPV16/18+ or (HPV31/33/35/45/52/58+ and ASC-US+) | |||||||
All | 1926 | 110 | 28 | 1 | 146,631.02 | 7.16 | − 56,314.78 |
< 35 | 162 | 14 | 6 | 0 | 20,133.36 | − 5.49 | − 89,384.22 |
35–50 | 1049 | 63 | 15 | 0 | 83,106.61 | 6.03 | − 7044.19 |
50+ | 715 | 33 | 7 | 1 | 43,391.05 | 6.62 | 40,113.63 |
8 types+ or (HPV39/51/56/59/66/68+ and p16+) | |||||||
All | 3526 | 38 | 17 | 1 | 116,343.87 | − 1.57 | − 136,147.85 |
< 35 | 298 | 7 | 5 | 0 | 16,954.95 | − 5.85 | − 90,746.85 |
35–50 | 1940 | 24 | 9 | 0 | 67,049.77 | 0.63 | − 59,102.95 |
50+ | 1288 | 7 | 3 | 1 | 32,339.15 | 3.65 | 13,701.95 |
8 types+ or (HPV39/51/56/59/66/68+ and ASC-US+) | |||||||
All | 3450 | 46 | 18 | 1 | 121,105.72 | − 3.34 | − 163,236.48 |
< 35 | 293 | 8 | 5 | 0 | 17,463.29 | − 6.03 | − 93,525.71 |
35–50 | 1897 | 27 | 10 | 0 | 69,402.24 | − 0.48 | − 75,456.96 |
50+ | 1260 | 11 | 3 | 1 | 34,240.19 | 3.17 | 5746.19 |