Fig. 3
From: Precision therapeutic targets for HPV-positive cancers: an overview and new insights
Immune evasion leads by HPV E5 protein. Without E5, the antigens are proteolytically degraded to antigenic peptides, which bind to MHC in the endoplasmic reticulum to become the MHC complex and are delivered to the cell membrane. However, in the presence of E5, MHC is retained in the endoplasmic reticulum. Created in BioRender.com