Fig. 3

MR analysis for JAK-STAT-DEGs and CRC. a Results of MR analysis of 66 JAK-STAT-DEGs. b Using RT-qPCR assay, we found that ANK3 gene was significantly down-regulated in CRC samples compared to control samples. c The effect of SNPs of ANK3 on CRC correlated to overall. d Relationship between ANK3 and prognosis of CRC. e MR analysis of ANK3 and CRC. f Sensitivity analysis shows that the results are reliable