Fig. 1

Flowchart of the Study Protocol. The study included women with histologically confirmed CIN2-CIN3 who underwent cervical conization. Among these, women with HPV infection post-conization were tested for HPV integration within 3 months. Then follow-up visits were conducted at 6-month intervals, totaling two rounds of screening. The flowchart details the distribution of HPV integration results and subsequent outcomes at the 1-year follow-up. No recurrent/residual CIN after conization was defined by completely negative cervical biopsy results under colposcopy. Abbreviations: LEEP, loop electrosurgical excision procedure; CKC, cold knife conization; HPV, human papillomavirus