An exploratory study on the differential diagnostic indicators between adult systemic EBV-positive T-cell lymphoproliferative disorders and angioimmunoblastic T-cell lymphoma with multiple EBV infections

Table 4 Mutation status of the 7 cases of AITL

Case number	Concen-tration (ng/ul)	Ladder (bp)	Results	Mutation frequency	Depth
1	137.8	600	TET2:NM_001127208.2:exon11:c.4662_4663del: p.E1555Vfs*22 TET2:NM_001127208.2:exon8:c.3986T > C:p.L1329P DNMT3A: NM_022552.4:exon16:c.1910T > G:p.L637R DNMT3A: NM_022552.4:exon8:c.928 A > T:p.I310F KMT2B: NM_014727.2:exon28:c.6190G > A:p.V2064M RHOA: NM_001664.4:exon2:c.50G > T:p.G17V	19% 11% 13% 5% 7% 4%	149x 73x 141x 268x 220x 135x
2	97.1	400	DNMT3A c.2678G > C:p.W893S TET2 c.1212delG: p.L404fs TET2 c.2286delC: p.H762fs VAV1 c.748 C > T:p.R250C RHOA c.50G > T:p.G17V IDH2 c515G > A:p.R172K TET2 c.3955–2 A > G SETD2 c.2514 2516delCTA: p.S838del	23% 12% 23% 38% 11% 9% 8% 42%	100x 76x 158x 143x 210x 124x 89x 156x
3	75.9	500	EP300:NM_001429.4;c.3677T > C;p.11226T NF1;NM_001042492.2;c10161019dup; p.V341Lfs13 RHOA; NM_001664.4;c.50G > T;p.G17V SIN3A; NM_015477.3;c.974 A > G;p.Y325C STAT3;NM_139276.2;c.1852G > C;p.G618R TET2:NM_001127208.2;c.4618 C > T;p.01540 TET2:NM_001127208.2:c.3581 3587del; p.P1194Lfs*30	36% 33% 38% 4% 41% 38% 32%	130x 178x 165x 230x 126x 134x 200x
4	30.2	600	B2M: NM_004048.3:exon2:c.294T > A:p.Y98* TET2:NM_001127208.2:exon3:c.2272_2273del: p.Q758Dfs10 TET2:NM_001127208.2:exon11:c.4636 C > T:p.Q1546 TET2:NM_001127208.2:exon9:c.4151 A > G:p.D1384G RHOA: NM_001664.4:exon2:c.50G > T:p.G17V	22% 21% 19% 5% 16%	106x 113x 187x 139x 96x
5	149.8	100 (unqualified)
6	106.7	100 (unqualified)
7	32.3	100 (unqualified)

ISSN: 1750-9378