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Fig. 2 | Infectious Agents and Cancer

Fig. 2

From: An exploratory study on the differential diagnostic indicators between adult systemic EBV-positive T-cell lymphoproliferative disorders and angioimmunoblastic T-cell lymphoma with multiple EBV infections

Fig. 2

Morphology and immunohistochemical/in-situ hybridisation markers for AITL (A, B, H&E; C, CD4; D, CD8; E, PD1; F, ICOS; G, CXCL13; H, CD10; I, Bcl-6; J, EBER; K, EBER/CD3; L, EBER/CD20). A, B The lymph node structure is destroyed and has obvious vascular proliferation and abundant histocytes, the tumour cells are medium-large size, with irregular nuclei, small nucleoli, empty cytoplasm and mitoses are easily visible. C, D Tumour cells are predominantly CD4-positive T cells. E-I Tumour cells strongly and diffusely express TFH cell markers. J EBER-ISH positive, multiple EBER-positive cells with large, medium and small cells, K, L Double in-situ hybridisation and immunohistochemistry for EBER and CD3/CD20 showed EBV-infected mainly B cells and fewer T cells (EBER, brown; CD3/CD20, red)

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Infectious Agents and Cancer

ISSN: 1750-9378

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