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Fig. 1 | Infectious Agents and Cancer

Fig. 1

From: An exploratory study on the differential diagnostic indicators between adult systemic EBV-positive T-cell lymphoproliferative disorders and angioimmunoblastic T-cell lymphoma with multiple EBV infections

Fig. 1

Morphology and immunohistochemical/in-situ hybridisation markers for adult systemic EBV+ T-LPD (A, B, H&E; C, CD4; D, CD8; E, PD1; F, ICOS; G, CXCL13; H, CD10; I, Bcl-6; J, EBER; K, EBER/CD3; L, EBER/CD20). A, B The lymph node structure is destroyed, mixed cellular composition characterised by predominantly small to medium-sized tumour cells with slightly irregular nuclei, with an increased presence of histocytes and vessels. C, D Tumour cells are predominantly CD4-positive T cells. E-I The expression of TFH cell markers, except that some cells in the residual germinal center are positive, tumour cells barely express TFH markers, a few cells can weakly-moderately express ICOS. J EBER-ISH positive, with a predominance of small and medium cells. K Double in-situ hybridisation and immunohistochemistry for EBER and CD3 showed EBV-infected mainly T cells (EBER, brown; CD3, red). L, Double in-situ hybridisation and immunohistochemistry for EBER and CD20 showed EBV-infected fewer B cells (EBER, brown; CD20, red)

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Infectious Agents and Cancer

ISSN: 1750-9378

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