The current state of DNA methylation biomarkers in self-collected liquid biopsies for the early detection of cervical cancer: a literature review

Table 2 Methylation detection of CIN3 + in hrHPV + urine samples from referral populations

Marker	n=	AUC	95% CI	Study
ST6GALNAC5	33	0.628	0.453–0.804	Van Keer, 2021
ZIC1	33	0.558	0.400-0.742	Van Keer, 2021
ZIC1	74	0.62	0.47–0.77	van den Helder, 2020
ZIC1	245	0.72	0.66–0.78	van den Helder, 2022
LHX8	74	0.68	0.54–0.82	van den Helder, 2020
LHX8	33	0.682	0.465–0.842	Van Keer, 2021
LHX8	245	0.78	0.72–0.83	van den Helder, 2022
SST	33	0.634	0.473–0.809	Van Keer, 2021
SST	245	0.72	0.65–0.79	van den Helder, 2022
SST	74	0.73	0.59–0.86	van den Helder, 2020
GHSR	74	0.7	0.56–0.84	van den Helder, 2020
GHSR	33	0.769	0.561–0.897	Van Keer, 2021
GHSR	245	0.79	0.72–0.84	van den Helder, 2022
ASCL1	33	0.566	0.473–0.849	Van Keer, 2021
ASCL1	74	0.79	0.67–0.91	van den Helder, 2020
ASCL1	245	0.83	0.77–0.88	van den Helder, 2022
ASCL1/LHX8	245	0.84	0.78–0.89	van den Helder, 2022

ISSN: 1750-9378