Table 2 Agreement between ScreenFire HPV RS assay Zebra BioDome format (M5FHPV-96) and ScreenFire HPV RS assay standard format (M5FHPV-100) for detection of HPV RS genotypes
HPV Results (M5FHPV-96 vs. M5FHPV-100) | +/+ n(%) | -/+ n(%) | +/- n(%) | -/- n(%) | Positive agreement % (95% CI) | Negative agreement % (95% CI) | Overall agreement % (95% CI) | Unweighted kappa (95% CI) |
|---|---|---|---|---|---|---|---|---|
HPV16 | 36 (20.8) | 3 (1.7) | 1 (0.6) | 133 (76.9) | 92.3 (79.1–98.4) | 99.3 (95.9–100) | 97.7 (94.2–99.4) | 0.93 (0.87-1) |
HPV18/45 | 27 (15.6) | 1 (0.6) | 1 (0.6) | 144 (83.2) | 96.4 (81.7–99.9) | 99.3 (96.2–100) | 98.8 (95.9–99.9) | 0.96 (0.9-1) |
HPV31/33/35/52/58 | 18 (10.4) | 0 (0) | 2 (1.2) | 153 (88.4) | 100 (81.5–100) | 98.7 (95.4–99.8) | 98.8 (95.9–99.9) | 0.94 (0.86-1) |
HPV39/51/56/59/68 | 11 (6.4) | 0 (0) | 0 (0) | 162 (93.6) | 100 (71.5–100) | 100 (97.7–100) | 100 (97.9–100) | 1 (1–1) |