Insight into the mechanisms regulating liver cancer stem cells by hepatitis B virus X protein

Table 2 The factors involved in the regulation of LCSC-associated epigenetic alterations induced by HBX

Epigenetic factors	Target molecules involved in epigenetic regulation	The role of HBX on target molecule	References
DNA methylation	EZH2	Inhibition	[86]
Histone methylation	SUZ12	Inhibition	[88]
Histone methylation	KDM5B, WDR5	Activation/Upregulation	[89, 90]
microRNA	miR-181, miR-5188, miR-199a-3p, miR-3682-3p	Upregulation	[16, 28, 93, 94]
microRNA	miR-124	Inhibition	[95]
LncRNA	lncRNA-MALAT1	Upregulation	[95]

ISSN: 1750-9378