Table 2 BHRF miRNAs and their functions
From: From virus to cancer: Epstein–Barr virus miRNA connection in Burkitt's lymphoma
MIRNA | Function | Implications in Burkitt lymphoma |
|---|---|---|
MIR-BHRF1-1 | Targets chemokine (C-X-C motif) ligand 11 (CXCL11) and downregulates p53 upregulated modulator of apoptosis (PUMA) | Modulates immune response, aiding in immune evasion and lymphoma progression [94] |
MIR-BHRF1-2 | EBV-miR-BHRF1-2 targets PRDM1 | Promotes EBV lymphomagenesis [13] |
MIR-BHRF1-3 | Downregulates the 3'UTR of the BZLF1 gene an immediate-early transcriptional activator | Promotes tumor growth and metastasis by altering cell signaling pathways, maintain EBV latency in Burkitt lymphoma cells [14] |
MIR-BHRF1-1 | Targets chemokine (C-X-C motif) ligand 11 (CXCL11) and downregulates p53 upregulated modulator of apoptosis (PUMA) | Modulates immune response, aiding in immune evasion and lymphoma progression [94] |