Table 1 BART miRNAs and their functions
From: From virus to cancer: Epstein–Barr virus miRNA connection in Burkitt's lymphoma
Bart micro-RNAS | Function | Implications in Burkitt lymphoma |
|---|---|---|
MIR-BART1 | Modulates apoptosis, targets genes involved in cell cycle regulation | Suppresses Th1 cell differentiation, targets of miR-BART1 in BL include PSAT1 (metabolic enzyme), CTSB (lysosomal protease), and LY75 (regulates Th1 cell differentiation) [44] |
MIR-BART2 | Targets the mRNA of the viral DNA polymerase BALF5targeting MICB, an NKG2D ligand | Reduces viral DNA replication, helping the virus persist in latent state in lymphoma evade recognition and killing by NK cells [91] |
MIR-BART3 | Targets and downregulates the tumor suppressor gene TP53 | Enhance Cell survival [91] |
MIR-BART6 | Targets genes involved in the immune response, including HLA class I molecules, IL-6R and, PTEN | Promoting cell proliferation through the activation of NF-κB and PI3K/Akt signaling pathways, respectively [92] |
MIR-BART9 | Targets and suppresses the expression of FOXO3 | Promoting lytic reactivation in BL cells [93] |