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Table 2 Demographics and Baseline Variables by bone marrow involvement

From: Real-world treatment outcomes for Hodgkin lymphoma in South Africa: a prospective observational study

 

Bone Marrow Involved

(N = 22)

Bone Marrow un-Involved

(N = 25)

p-Value

Age, year's (IQR)

42.0 (39.0–47.8)

34.0 (32.0–44.0)

0.0451

Sex (n)

   

 Male

68% (15)

36% (9)

0.0282

 Female

32% (7)

64% (16)

Race (n)

   

 Black

91% (20)

84% (21)

0.2042

 White

0% (0)

12% (3)

 Coloured

9% (2)

4% (1)

ECOG PS (n)

   

 0 or 1

32% (7)

56% (14)

0.0962

 ≥ 2

68% (15)

44% (11)

B Symptoms (n)

   

 Present

100% (22)

96% (24)

0.3432

 Absent

0% (0)

4% (1)

Stage (n)

   

 1 or 2

0% (0)

24% (2)

0.0142

 3 or 4

100% (22)

76% (29)

HIV status (n)

   

 Positive

91% (20)

44% (11)

 < 0.0012

 Negative

9% (2)

56% (14)

IPS (n)

   

 < 4

0% (0)

72% (18)

 < 0.0012

 ≥ 4

100% (22)

28% (7)

CD4, cells/μL (IQR)

74.5 (48.0–110.8)

299.0 (265.5–468.0)

 < 0.0011

HIV Viral Load, copies/mL (n)

   

 < 200

90% (18)

64% (7)

0.0752

 ≥ 200

10% (2)

36% (4)

TB Treatment (n)

   

 No

73% (16)

92% (23)

0.0792

 Yes

27% (6)

8% (2)

WBC, 109/L (IQR)

2.9 (2.0–5.3)

10.3 (4.6–14.4)

 < 0.0011

Hemoglobin, g/dL (IQR)

7.8 (6.1–8.5)

9.9 (9.3–12.0)

 < 0.0011

Platelet, 109/L (IQR)

91.0 (29.8–182.8)

495.0 (306.0–587.0)

 < 0.0011

ALC, 109/L (IQR)

0.5 (0.3–0.6)

1.4 (1.1–2.1)

 < 0.0011

Albumin, g/L (IQR)

24.5 (22.2–28.8)

35.0 (31.0–41.0)

 < 0.0011

EBER Evaluable (n)

   

 Positive

93% (14)

38% (5)

0.0022

 Negative

7% (1)

62% (8)

  1. For continuous variables, the median and IQR are shown. N is the number of non–missing values and n are frequencies. Tests used: 1Wilcoxon test; 2Pearson’s chi-squared test test. Abbreviations: IQR: Interquartile range; ECOG PS: Eastern Cooperative Oncology Group Performance Status; IPS: International Prognostic Score; TB: Tuberculosis; WBC: White blood cell; ALC: Absolute lymphocyte count