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Table 4 Associations between risk factors and log-transformed KSHV viral loads among KSHV shedders (n = 149)

From: Factors affecting Kaposi’s sarcoma-associated herpesvirus transmission in rural Ugandan households, a longitudinal study

 

Crude Estimates

Adjusted Estimates

Risk Factors

Beta(95%CI)

p-value

Beta(95%CI)

p-value

Sex - Female vs. Malea, b

-0.17(-0.64,0.29)

0.461

-0.07(-0.55,0.41)

0.778

Age (years) – continuousb

-0.01(-0.02,0.01)

0.168

-0.01(-0.02,0.01)

0.260

Age (years)b, c

 

0.046*

 

0.027*

 1–4 years

REF

REF

 5–9 years

-0.26(-1.27,0.75)

0.612

-0.39(-1.39,0.61)

0.443

 10–14 years

0.65(-0.34,1.63)

0.197

0.61(-0.36,1.58)

0.213

 15–19 years

0.36(-0.72,1.45)

0.510

0.36(-0.71,1.43)

0.506

 20–29 years

-0.11(-1.27,1.05)

0.852

-0.19(-1.33,0.95)

0.743

 30–39 years

-0.53(-1.76,0.70)

0.397

-0.43(-1.64,0.78)

0.485

 40 + years

-0.31(-1.32,0.71)

0.555

-0.37(-1.37,0.62)

0.460

Socioeconomic Status Quintilesb, c

 

0.917

 

0.877

 Highest

REF

REF

 Fourth

0.23(-0.35,0.80)

0.434

0.32(-0.28,0.91)

0.294

 Middle

0.02(-0.69,0.72)

0.966

0.25(-0.48,0.97)

0.500

 Second

-0.01(-0.77,0.77)

0.996

0.26(-0.55,1.07)

0.525

 Lowest

0.42(-1.46,2.29)

0.661

0.41(-1.47,2.29)

0.666

Number of Household Members – continuousc

0.05(-0.01,0.11)

0.113

0.06(0.01,0.12)

0.042*

Number of KSHV Seropositive Household Members – continuousc

0.07(0.01,0.13)

0.036*

0.08(0.01,0.15)

0.021*

Sick individual in home at time of visit – yes vs. no,c

-0.42(-1.04,0.20)

0.182

-0.35(-1.01,0.31)

0.291

EBV Status - Seropositive vs. Seronegative

0.60(-1.98,3.19)

0.645

--

Individual HIV Serostatus – positive vs. negativea, b

0.06(-0.62,0.74)

0.860

0.67(-0.1,1.43)

0.086

Household HIV Status – At least one PLWH vs. No PLWH b

0.40(-0.06,0.87)

0.087

0.51(0.04,0.98)

0.033*

Total Study Visitsa

 

0.284

 

0.217

 1

REF

REF

 2

0.32(-0.80,1.44)

0.571

-0.17(-1.30,0.97)

0.769

 3

0.64(-0.24,1.53)

0.153

0.43(-0.45,1.32)

0.335

Always vs. Intermittent shedder (n = 140)

1.62(1.19,2.05)

< 0.001*

--

Number of Visits with KSHV Shedding

 

< 0.001*

 

 1

REF

--

 2

1.04(0.58,1.50)

< 0.001*

 3

2.01(1.57,2.44)

< 0.001*

  1. *p < 0.05 considered statistically significant
  2. All models included a random intercept and random slope for household.
  3. aAdjusted for Age (categorical)
  4. bAdjusted for number household members
  5. cAdjusted for household HIV status (any vs. none)