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Table 3 Risk factors associations with KSHV always vs. intermittent shedders (n = 140 shedders)

From: Factors affecting Kaposi’s sarcoma-associated herpesvirus transmission in rural Ugandan households, a longitudinal study

Risk Factors

Crude Estimates

Adjusted Estimates

OR (95% CI)

p

OR (95% CI)

p

Sex – Female vs. Malea

0.71(0.32,1.55)

0.381

0.80(0.33,1.95)

0.618

Age (years) – continuous

0.99(0.96,1.01)

0.210

-

Age (years)

 

0.039*

  

 1–4 years

REF

-

 5–9 years

0.98(0.08,11.55)

0.984

-

 10–14 years

5.85(0.63,54.60)

0.119

-

 15–19 years

5.90(0.57,60.98)

0.134

-

 20–29 years

1.98(0.14,28.56)

0.610

-

 30–39 years

0.90(0.04,18.01)

0.941

-

 40 + years

0.97(0.08,11.56)

0.980

-

Socioeconomic Status Quintiles

 

0.915

  

 Highest

REF

-

 Fourth

0.93(0.34,2.55)

0.881

-

 Middle

1.28(0.38,4.36)

0.688

-

 Second

1.01(0.25,4.13)

0.989

-

 Lowest

3.35(0.17,67.67)

0.426

-

Number of Household Members – continuous

Model did not converge

-

Number of Household KSHV Seropositive Members – continuous

1.11(0.99,1.24)

0.076

-

Sick individual in home at time of visit – yes vs. noa

0.91(0.29,2.79)

0.861

0.76(0.22,2.62)

0.662

EBV Serostatus – seropositive vs. seronegativea

> 999.9(< 0.01,>999.9)

0.985

> 999.9(< 0.01,>999.9)

0.995

Individual HIV Serostatus – positive vs. negativea

0.91(0.17,4.92)

0.908

3.48(0.30,40.52)

0.310

Household HIV Status – At least one PLWH vs. No PLWH

1.41(0.64,3.11)

0.391

-

Total Study Visits

    

 2

REF

-

 3

0.42(0.13,1.38)

0.152

-

  1. Acronyms Used: Antiretroviral therapy (ART), Epstein Barr Virus (EBV), Kaposi’s sarcoma-associated herpesvirus (KSHV), Human Immunodeficiency Virus (HIV), People living with HIV (PLWH)
  2. KSHV seropositivity was defined as detection of anti-KSHV IgG antibodies to K3, K5, K6, K8, K11, K8.1, K10.5, K14, ORF11, ORF18, ORF19, ORF2, ORF20, ORF25, ORF26, ORF33, ORF34, ORF35, ORF37, ORF38, ORF43, ORF44, ORF45, ORF50, ORF52, ORF55, ORF59, ORF6, ORF60, ORF61, ORF63, ORF65, ORF69, ORF72, or ORF73.
  3. EBV seropositivity was defined as detection of anti-EBV IgG antibodies to VCA or EBNA-1.
  4. p-values < 0.05 considered statistically significant.
  5. All models included a random intercept and random slope for household.
  6. aAdjusted for age (categorical)