Table 1 The effects of gut microbiota on different methods in cancer treatment
From: Gastrointestinal cancer resistance to treatment: the role of microbiota
Bacteria | Therapy | Cancer type | Major findings | References |
|---|---|---|---|---|
Chemotherapy | ||||
 Gammaproteobacteria | Gemcitabine | Colon cancer mouse model | Gemcitabine resistance was induced by intratumor Gammaproteobacteria, dependent on bacterial CDDL expression | [83] |
 Barnesiella intestinihominis | Cyclophosphamide(CP) | Cancer lesions | The gram-negative Barnesiella intestinihominis was found to improve interferon-c–producing T cell infiltration in cancer lesions to enhance the antitumor effects of CP | [84] |
Immunotherapy | ||||
 Bacteroides thetaiotaomicron and Bacteroides fragilis | Anti-CTLA-4 | Mouse sarcoma, melanoma, colon | Th1 induction, DC maturation (IL-12 production) | [85] |
Radiotherapy | ||||
 Lactobacillus rhamnosus GG (LGG) | Radiation | Mouse model | LGG reduces radiation-induced intestinal epithelial injury and improve crypt survival | [86] |