Comparison of the ScreenFire and Xpert HPV assays for the detection of human papillomavirus and cervical precancer among women living with HIV in Malawi

Table 4 Hierarchical ScreenFire positivity compared to Xpert for self-collected specimens among 315 women in Malawi

ScreenFire self-collected (hierarchical)	Xpert self-collected reference standard (hierarchical)
ScreenFire self-collected (hierarchical)	HPV 16	Else HPV 18/45	Else HPV 31/33/35/52/58	Else HPV 51/59	Else HPV 39/56/66/68	Else HPV negative	Total
CIN2 + *
HPV 16	15	0	0	0	0	0	15
Else HPV 18/45	0	6	0	0	0	0	6
Else HPV 31/33/35/52/58	0	1	19	0	0	0	20
Else HPV 39/51/56/59/68	0	0	3	1	2	0	6
Else HPV negative	0	0	1	0	1	0	2
Total	15	7	23	1	3	0	49
< CIN2^†
HPV 16	31	1	1	0	1	Unknown^††	Unknown^††
Else HPV 18/45	0	29	0	0	1	Unknown^††	Unknown^††
Else HPV 31/33/35/52/58	2	5	93	0	3	Unknown^††	Unknown^††
Else HPV 39/51/56/59/68	4	3	4	19	8	Unknown^††	Unknown^††
Else HPV negative	7	3	6	3	6	Unknown^††	Unknown^††
Total	44	41	104	22	19	36	266

Italics are concordant HPV risk group results between the two assays
*Includes 14 cervical intraepithelial neoplasia grade 2 (CIN2), 35 cervical intraepithelial neoplasia grade 3 (CIN3)
^†Includes 21 cervical intraepithelial neoplasia grade 1 (CIN1) and 245 with normal pathology
^†† Results unknown as samples were not stored and hence not available for ScreenFire testing

ISSN: 1750-9378