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Table 1 The clinical-pathological features of the three groups of patients

From: PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome

Variable

 

Groups (n = 89)

 

Category

CM/ESCC (n = 23)

ESCC (n = 38)

CM (n = 28)

p-value

Gender

Female

4 (17.4%)

7 (18.4%)

4 (14.3%)

0.937**

Male

19 (82.6%)

31 (81.6%)

24 (85.7%)

Age (years)

Mean (SD)

59 (11)

57 (9)

59 (11)

0.039 ***

Min - Max

37–76

36–75

37–76

Alcohol consumption

No

7 (31.8%)

8 (21.1%)

20 (71.4%)

< 0.001 *

Yes

15 (68.2%)

30 (78.9%)

8 (28.6%)

Missing

11

0

0

 

Tobacco consumption

No

4 (18.2%)

6 (15.8%)

16 (57.1%)

< 0.001 *

Yes

18 (81.8%)

32 (84.2%)

12 (42.9%)

Missing

1

0

0

 

Tumor differentiation

Well differentiated

5 (22.7%)

7 (19.4%)

NA

0.639**

Moderate differentiated

16 (72.7%)

24 (66.7%)

NA

Poorly differentiated

1 (4.5%)

5 (13.9%)

NA

Missing

1

2

NA

 

TNM Staging

I/II

4 (23.5%)

16 (42.1%)

NA

0.235*

III/IV

13 (76.5%)

22 (57.9%)

NA

Missing

6

0

NA

 

Megaesophagus grades

GI/GII

10 (45.5%)

NA

4 (14.3%)

0.025 *

GIII/GIV

12 (54.5%)

NA

24 (85.7%)

Missing

1

NA

0

 
  1. *Chi-square association test; **Fisher’s exact test; ***Analysis of variance. CM/ESCC – chagasic megaesophagus associated with esophageal squamous cell carcinoma; ESCC – esophageal squamous cell carcinoma without chagasic megaesophagus; CM – chagasic megaesophagus without esophageal squamous cell carcinoma; SD - standard deviation; NA – not applicable; Bold numbers - statistical significanceÂ